DECELLULARIZED MATRICES

TissueGraft provides biological matrices, obtained through a decellularization process of animal soft tissues. The decellularization process involves a combination of chemical, physical and enzymatic processes to remove the cell material from the tissues. The decellularized matrices supplied by TissueGraft reach very high standards regarding DNA content, which is below the established legal limits. The decellularization process eliminates any risk of immune response on the matrix by the host and / or any form of rejection, ensuring the preservation of the physiological tissue composition necessary for cellular functions.

HYDROGEL

The term hydrogel defines a group of three-dimensional cross-linked polymeric based materials, characterized by its extraordinary ability to absorb water or other fluids without losing them. This property gives it a great interest, in particular in regenerative medicine field. The decellularized matrix is processed in order to obtain the hydrogel. The first step is performed through decellularized matrix lyophilization and pulverization. The second step is an enzymatic digestion, optimized to obtain the optimal protein concentration for hydrogel production, which will take place through a gelation process.

NANOVESICLES

The advantages of TissueGraft products are now also available in the nanosize! TissueGraft develops extracellular vesicles known as matrix bound nanovesicles. These nanomaterials are loaded with extracellular matrix components, they can be resuspended in any solution and used for regenerative medicine applications, or they can be used to enrich your biomaterials.

ELECTROSPUN MATERIALS

Electrospun matrices are of considerable importance for academic research in tissue engineering and regenerative medicine fields. Indeed, through the electrospinning process we can adjust the rheological properties of the matrix, in particular in terms of porosity, thickness, rigidity and numerous other parameters. The decellularized matrix is subjected to different treatments for obtaining an electrospun matrix.

EXTRACELLULAR MATRIX POWDERS

The decellularized matrix can be provided in powder formulation derived from freeze-drying and subsequent pulverization process of the decellularized bovine pericardium.

DECELLULARIZED ORGANS

The decellularization process can also be performed on whole organs, such as liver and kidney, in order to use the parenchyma as a substrate for organ regeneration studies.