TissueGraft provides biological matrices, obtained through a decellularization process of animal soft tissues. The decellularization process involves a combination of chemical, physical and enzymatic processes to remove the cell material from the tissues. The decellularized matrices supplied by TissueGraft reach very high standards regarding DNA content, which is below the established legal limits. The decellularization process eliminates any risk of immune response on the matrix by the host and / or any form of rejection.
The decellularization process can also be performed on whole organs, such as liver and kidney, in order to use the parenchyma as a substrate for organ regeneration studies.
EXTRACELLULAR MATRIX POWDERS
The decellularized matrix can be provided in powder formulation derived from freeze-drying and subsequent pulverization process of the decellularized bovine pericardium.
The term hydrogel defines a group of three-dimensional cross-linked polymeric based materials, characterized by its extraordinary ability to absorb water or other fluids without losing them. This property gives it a great interest, in particular in regenerative medicine field. The decellularized matrix is processed in order to obtain the hydrogel. The first step is performed through decellularized matrix lyophilization and pulverization. The second step is an enzymatic digestion, optimized to obtain the optimal protein concentration for hydrogel production, which will take place through a gelation process.
Electrospun matrices are of considerable importance for academic research in tissue engineering and regenerative medicine fields. Indeed, through the electrospinning process we can adjust the rheological properties of the matrix, in particular in terms of porosity, thickness, rigidity and numerous other parameters. The decellularized matrix is subjected to different treatments for obtaining an electrospun matrix.
TissueGraft matrices can be enriched with bioactive molecules (antibiotics, growth factors, anticoagulants, peptides, etc.), through a unique process, defined by the trademark sueGraft®, making it possible to change the functionalization molecular type according to customer needs, adapting these matrices to the most diverse practical needs.