Natural Science and Engineering Research Council of Canada

Collaborative research development project

“Effect of plasma treatments on natural materials – in particular polysaccharides and collagen – for biotechnologicla applications in health”. 

Funded by Government of Canada and Government of Quebec, in collaboration with Plasmionique inc.

Research center “E. Piaggio” of Pisa

Collaboration for electrospun materials’ development.



SIMCRI: Italian society of polyspecialist regenerative medicine and surgery.
This society promotes the research in every field of polyspecialist regenerative medicine and surgery encouraging the dissemination of culture through scientific meetings in Italy and Europe and scientific publications. This society will follow TissueGraft during Clinical Trials in Italy.



The Department of Chemistry, Materials and Chemical Engineering “G. Natta” of Politecnico di Milano gathers about 100 researchers and professors who work in different research fields of chemistry, materials engineering and bioengineering. TissueGraft actively collaborates with prof. Silvia Farè and the Be2fore Laboratory, Biomaterials and Biofabrication for regenerative engineering. The laboratory mainly deals with the synthesis and modification of synthetic and natural polymeric materials, the fabrication of scaffolds for applications in regenerative medicine and tissue engineering fields through traditional processes, electrospinning and additive manufacturing, and morphological, chemical. physical and mechanical characterization.



L’Universitè Laval, located in Quebec City is the oldest research institute in Canada. Today has more than 350 courses and about. 40.000 students. With more than 300M$/ year of grants, Universitè Laval is a leader in scientific research and technology transfer. It counts more than 40 research centers, more than 600 patents and 25 spin-off.
The collaboration is active between TissueGraft and the Laboratory for Biomaterials and Bioengineering represented by Prof. Diego Mantovani: the laboratory is at the forefront for what concern the translational research and new application in the field of biomaterials.


Nobil Bio Ricerche srl is an ISO9001 and ISO13485 qualified company for the surface treatment and characterization of implantable medical devices. The company performs analysis and surface treatment of medical materials and is active in their characterization through chemico-physical and biological in vitro techniques. The core business is the surface treatment of dental implants (several hundreds of thousands per year), performed for dental implants producer companies. Beside this activity the company is now developing the production and commercialization of dental materials for bone regeneration.


ISALIT is a spin-off of the Department of Science and Technological Innovation at the University of Piemonte Orientale. ISALIT has an equipped chemical laboratory with an high resolution mass spectrometer: the system comprised micro-liquid chromatography (Eksigent Technologies, Dublin, USA) interfaced with an high resolution 5600+ TripleTOF (AB Sciex, Concord, Canada ).
The instrumentation is particularly suitable for qualitative and quantitative proteomic analysis (with the label-free SWATH-MS mode) for metabolic analysis and for non-target studies and biomarker discovery. The system can also use the SWATH-MS for pseudo-MRM analysis on target proteins.
This instrumentation enables quantitative and qualitative analyses with extraordinary accuracy and sensitivity of biological, food and environmental samples. The ability to carry out rapid screening of many metabolites and proteins through HPLC-HRMS coupled with statistical data processing allows the identification of new bio-markers, drugs, and other molecules of interest. The analysis of biological fluids such as blood, serum, plasma, urine, saliva as well as tissues can be performed.
The ISALIT team uses bioinformatics software for pathway analysis, protein network interactions (enriched paths, biological functions, molecular functions, etc.) and multivariate analysis of large data with commercial statistical software and custom tool for validation of analytical methods and biomarkers .
ISALIT has specific expertise in the field of proteomics and metabolomics analysis and has a strong track record of collaboration with research institutes, universities and hospitals.